A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans

A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans

piRNAs play a critical role in the regulation of transposons and other germline genes. In Caenorhabditis elegans, regulation of piRNA target genes is mediated by the mutator complex, which synthesizes high levels of siRNAs through the activity of an RNA-dependent RNA polymerase. However, the steps b...

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Bibliographic Details
Main Authors: Kevin I Manage, Alicia K Rogers, Dylan C Wallis, Celja J Uebel, Dorian C Anderson, Dieu An H Nguyen, Katerina Arca, Kristen C Brown, Ricardo J Cordeiro Rodrigues, Bruno FM de Albuquerque, René F Ketting, Taiowa A Montgomery, Carolyn Marie Phillips
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
piRNAs
siRNAs
germline
RNA silencing
germ granules
nuage
Online Access:https://elifesciences.org/articles/56731

Internet

https://elifesciences.org/articles/56731

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