A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans

A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans

piRNAs play a critical role in the regulation of transposons and other germline genes. In Caenorhabditis elegans, regulation of piRNA target genes is mediated by the mutator complex, which synthesizes high levels of siRNAs through the activity of an RNA-dependent RNA polymerase. However, the steps b...

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Bibliografski detalji
Glavni autori: Kevin I Manage, Alicia K Rogers, Dylan C Wallis, Celja J Uebel, Dorian C Anderson, Dieu An H Nguyen, Katerina Arca, Kristen C Brown, Ricardo J Cordeiro Rodrigues, Bruno FM de Albuquerque, René F Ketting, Taiowa A Montgomery, Carolyn Marie Phillips
Format: Članak
Jezik:English
Izdano: eLife Sciences Publications Ltd 2020-04-01
Serija:eLife
Teme:
piRNAs
siRNAs
germline
RNA silencing
germ granules
nuage
Online pristup:https://elifesciences.org/articles/56731

Internet

https://elifesciences.org/articles/56731

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