A New Mild Method for Synthesis of Marine Alkaloid Fascaplysin and Its Therapeutically Promising Derivatives

A New Mild Method for Synthesis of Marine Alkaloid Fascaplysin and Its Therapeutically Promising Derivatives

Fascaplysin is a marine alkaloid which is considered to be a lead drug candidate due to its diverse and potent biological activity. As an anticancer agent, fascaplysin holds a great potential due to the multiple targets affected by this alkaloid in cancer cells, including inhibition of cyclin-depend...

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Bibliographic Details
Main Authors: Oleg A. Tryapkin, Alexey V. Kantemirov, Sergey A. Dyshlovoy, Vladimir S. Prassolov, Pavel V. Spirin, Gunhild von Amsberg, Maria A. Sidorova, Maxim E. Zhidkov
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Marine Drugs
Subjects:
fascaplysin derivatives
synthesis
UV quaternization
DNA intercalation
prostate cancer
cytotoxicity
Online Access:https://www.mdpi.com/1660-3397/21/8/424

Internet

https://www.mdpi.com/1660-3397/21/8/424

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