Cyclic Derivatives of the Chemerin C-Terminus as Metabolically Stable Agonists at the Chemokine-like Receptor 1 for Cancer Treatment

Cyclic Derivatives of the Chemerin C-Terminus as Metabolically Stable Agonists at the Chemokine-like Receptor 1 for Cancer Treatment

Chemerin is a small chemotactic protein and a modulator of the innate immune system. Its activity is mainly mediated by the chemokine-like receptor 1 (CMKLR1), a receptor expressed by natural killer cells, dendritic cells, and macrophages. Downregulation of chemerin is part of the immune evasion str...

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Bibliographic Details
Main Authors: Tobias F. Fischer, Anne S. Czerniak, Tina Weiß, Tristan Zellmann, Lina Zielke, Sylvia Els-Heindl, Annette G. Beck-Sickinger
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
chemerin
CMKLR1
peptides
peptide–drug conjugates
GPCR
Online Access:https://www.mdpi.com/2072-6694/13/15/3788

Internet

https://www.mdpi.com/2072-6694/13/15/3788

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