Inhibition of the Histone Methyltransferase EZH2 Enhances Protumor Monocyte Recruitment in Human Mesothelioma Spheroids

Inhibition of the Histone Methyltransferase EZH2 Enhances Protumor Monocyte Recruitment in Human Mesothelioma Spheroids

Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a long latency period and dismal prognosis. Recently, tazemetostat (EPZ-6438), an inhibitor of the histone methyltransferase EZH2, has entered clinical trials due to the antiproliferative effects reported on MPM cells. However,...

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Bibliographic Details
Main Authors: Silvia Mola, Giulia Pinton, Marco Erreni, Marco Corazzari, Marco De Andrea, Ambra A. Grolla, Veronica Martini, Laura Moro, Chiara Porta
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
malignant pleural mesothelioma
tumor-associated macrophages
monocytes
EZH2
spheroids
epigenetic reprogramming
Online Access:https://www.mdpi.com/1422-0067/22/9/4391

Internet

https://www.mdpi.com/1422-0067/22/9/4391

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