Pirfenidone increases IL-10 and improves acute pancreatitis in multiple clinically relevant murine models

Pirfenidone increases IL-10 and improves acute pancreatitis in multiple clinically relevant murine models

Despite decades of research, there is no specific therapy for acute pancreatitis (AP). In the current study, we have evaluated the efficacy of pirfenidone, an antiinflammatory and antifibrotic agent that is approved by the FDA for treatment of idiopathic pulmonary fibrosis (IPF), in ameliorating loc...

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Bibliographic Details
Main Authors: Ejas Palathingal Bava, John George, Mohammad Tarique, Srikanth Iyer, Preeti Sahay, Beatriz Gomez Aguilar, Dujon B. Edwards, Bhuwan Giri, Vrishketan Sethi, Tejeshwar Jain, Prateek Sharma, Utpreksha Vaish, Harrys K. C. Jacob, Anthony Ferrantella, Craig L. Maynard, Ashok K. Saluja, Rajinder K. Dawra, Vikas Dudeja
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-01-01
Series:JCI Insight
Subjects:
Gastroenterology
Inflammation
Online Access:https://doi.org/10.1172/jci.insight.141108

Internet

https://doi.org/10.1172/jci.insight.141108

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