Pyronaridine as a Bromodomain-Containing Protein 4-<i>N</i>-Terminal Bromodomain (BRD4-BD1) Inhibitor: <i>In Silico</i> Database Mining, Molecular Docking, and Molecular Dynamics Simulation

Pyronaridine as a Bromodomain-Containing Protein 4-<i>N</i>-Terminal Bromodomain (BRD4-BD1) Inhibitor: <i>In Silico</i> Database Mining, Molecular Docking, and Molecular Dynamics Simulation

BRD4 (bromodomain-containing protein 4) is an epigenetic reader that realizes histone proteins and promotes the transcription of genes linked to cancer progression and non-cancer diseases such as acute heart failure and severe inflammation. The highly conserved <i>N</i>-terminal bromodom...

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Bibliographic Details
Main Authors: Mahmoud A. A. Ibrahim, Mahmoud M. H. Abdelhamid, Khlood A. A. Abdeljawaad, Alaa H. M. Abdelrahman, Gamal A. H. Mekhemer, Peter A. Sidhom, Shaban R. M. Sayed, Paul W. Paré, Mohamed-Elamir F. Hegazy, Tamer Shoeib
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Molecules
Subjects:
cancer disease
bromodomain-containing protein 4
SuperDRUG2 database
molecular docking
molecular dynamics simulations
Online Access:https://www.mdpi.com/1420-3049/28/15/5713

Internet

https://www.mdpi.com/1420-3049/28/15/5713

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