Anti-V3 monoclonal antibodies display broad neutralizing activities against multiple HIV-1 subtypes.

Anti-V3 monoclonal antibodies display broad neutralizing activities against multiple HIV-1 subtypes.

The V3 loop of the HIV-1 envelope (Env) glycoprotein gp120 was identified as the "principal neutralizing domain" of HIV-1, but has been considered too variable to serve as a neutralizing antibody (Ab) target. Structural and immunochemical data suggest, however, that V3 contains conserved e...

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Bibliographic Details
Main Authors: Catarina E Hioe, Terri Wrin, Michael S Seaman, Xuesong Yu, Blake Wood, Steve Self, Constance Williams, Miroslaw K Gorny, Susan Zolla-Pazner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2858080?pdf=render

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http://europepmc.org/articles/PMC2858080?pdf=render

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