Host prion protein expression levels impact prion tropism for the spleen.

Host prion protein expression levels impact prion tropism for the spleen.

Prions are pathogens formed from abnormal conformers (PrPSc) of the host-encoded cellular prion protein (PrPC). PrPSc conformation to disease phenotype relationships extensively vary among prion strains. In particular, prions exhibit a strain-dependent tropism for lymphoid tissues. Prions can be com...

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Bibliographic Details
Main Authors: Vincent Béringue, Philippe Tixador, Olivier Andréoletti, Fabienne Reine, Johan Castille, Thanh-Lan Laï, Annick Le Dur, Aude Laisné, Laetitia Herzog, Bruno Passet, Human Rezaei, Jean-Luc Vilotte, Hubert Laude
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008283

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https://doi.org/10.1371/journal.ppat.1008283

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