Symmetrical dimethylation of H4R3: A bridge linking DNA damage and repair upon oxidative stress

Symmetrical dimethylation of H4R3: A bridge linking DNA damage and repair upon oxidative stress

The DNA lesions caused by oxidative damage are principally repaired by the base excision repair (BER) pathway. 8-oxoguanine DNA glycosylase 1 (OGG1) initiates BER through recognizing and cleaving the oxidatively damaged nucleobase 8-oxo-7,8-dihydroguanine (8-oxoG). How the BER machinery detects and...

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Bibliographic Details
Main Authors: Zhuang Ma, Wentao Wang, Shiwei Wang, Xingqi Zhao, Ying Ma, Congye Wu, Zhigang Hu, Lingfeng He, Feiyan Pan, Zhigang Guo
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Redox Biology
Subjects:
H4R3me2s
OGG1
FEN1
BER
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720308582

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http://www.sciencedirect.com/science/article/pii/S2213231720308582

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