Persistent hypoxia promotes myofibroblast differentiation via GPR‐81 and differential regulation of LDH isoenzymes in normal and idiopathic pulmonary fibrosis fibroblasts

Persistent hypoxia promotes myofibroblast differentiation via GPR‐81 and differential regulation of LDH isoenzymes in normal and idiopathic pulmonary fibrosis fibroblasts

Abstract Hypoxia, a state of insufficient oxygen availability, promotes cellular lactate production. Lactate levels are increased in lungs from patients with idiopathic pulmonary fibrosis (IPF), a disease characterized by excessive scar formation, and lactate is implicated in the pathobiology of lun...

Full description

Bibliographic Details
Main Authors: Richard S. Nho, Cami Rice, Jayendra Prasad, Hannah Bone, Laszlo Farkas, Mauricio Rojas, Jeffrey C. Horowitz
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Physiological Reports
Subjects:
G protein‐coupled receptor‐81 (GPR‐81)
hypoxia
idiopathic pulmonary fibrosis (IPF)
lactate dehydrogenase
α‐smooth muscle actin (α‐SMA)
Online Access:https://doi.org/10.14814/phy2.15759

Internet

https://doi.org/10.14814/phy2.15759

Similar Items