Plasma contains ultrashort single-stranded DNA in addition to nucleosomal cell-free DNA

Plasma contains ultrashort single-stranded DNA in addition to nucleosomal cell-free DNA

Summary: Plasma cell-free DNA is being widely explored as a biomarker for clinical screening. Currently, methods are optimized for the extraction and detection of double-stranded mononucleosomal cell-free DNA of ∼160bp in length. We introduce uscfDNA-seq, a single-stranded cell-free DNA next-generat...

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Bibliographic Details
Main Authors: Jordan Cheng, Marco Morselli, Wei-Lun Huang, You Jeong Heo, Thalyta Pinheiro-Ferreira, Feng Li, Fang Wei, David Chia, Yong Kim, Hua-Jun He, Kenneth D. Cole, Wu-Chou Su, Matteo Pellegrini, David T.W. Wong
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:iScience
Subjects:
Biological sciences
Molecular biology
Molecular biology experimental approach
Cell biology
Biological sciences research methodologies
Biology experimental methods
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222008264

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http://www.sciencedirect.com/science/article/pii/S2589004222008264

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