Multiomics analyses reveals Anaplasma phagocytophilum Ats-1 induces anti-apoptosis and energy metabolism by upregulating the respiratory chain-mPTP axis in eukaryotic mitochondria

Multiomics analyses reveals Anaplasma phagocytophilum Ats-1 induces anti-apoptosis and energy metabolism by upregulating the respiratory chain-mPTP axis in eukaryotic mitochondria

Abstract Background Anaplasma translocated substrate 1 (Ats-1) is an effector of type 4 secretory systems (T4SS) and the main virulence factor of Anaplasma phagocytophilum. Ats-1 is involved in the regulation of host cell biological processes, but the specific molecular mechanism of its action is un...

Full description

Bibliographic Details
Main Authors: Ruirui Li, Zhongchen Ma, Wei Zheng, Zhen Wang, Jihai Yi, Yangyang Xiao, Yong Wang, Chuangfu Chen
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Microbiology
Subjects:
Anaplasma phagocytophilum
Mitochondria
Ats-1
iTRAQ
PRM
Targeted metabonomics
Online Access:https://doi.org/10.1186/s12866-022-02668-x

Internet

https://doi.org/10.1186/s12866-022-02668-x

Similar Items