TGF-β2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells’ invasion

TGF-β2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells’ invasion

Abstract Background Glioblastoma multiforme (GBM) is characterized by lethal aggressiveness and patients with GBM are in urgent need for new therapeutic avenues to improve quality of life. Current studies on tumor invasion focused on roles of cytokines in tumor microenvironment and numerous evidence...

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Bibliographic Details
Main Authors: Chao Zhang, Xin Zhang, Ran Xu, Bin Huang, An-Jing Chen, Chao Li, Jian Wang, Xin-Gang Li
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Malignant brain tumor
Autophagy
TGF-β
Tumor invasion
Galunisertib
Online Access:http://link.springer.com/article/10.1186/s13046-017-0628-8

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http://link.springer.com/article/10.1186/s13046-017-0628-8

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