Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta

Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta

Amyloid protein aggregates are associated with dozens of devastating diseases including Alzheimer’s, Parkinson’s, ALS, and diabetes type 2. While structure-based discovery of compounds has been effective in combating numerous infectious and metabolic diseases, ignorance of amyloid structure has hind...

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Bibliographic Details
Main Authors: Lin Jiang, Cong Liu, David Leibly, Meytal Landau, Minglei Zhao, Michael P Hughes, David S Eisenberg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-07-01
Series:eLife
Subjects:
amyloid fiber
computational biology
drug discovery
Alzheimer's disease
ligand docking
Online Access:https://elifesciences.org/articles/00857

Internet

https://elifesciences.org/articles/00857

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