Hammerhead Ribozymes: True Metal or Nucleobase Catalysis? Where Is the Catalytic Power from?
The hammerhead ribozyme was first considered as a metalloenzyme despite persistent inconsistencies between structural and functional data. In the last decade, metal ions were confirmed as catalysts in self-splicing ribozymes but displaced by nucleobases in self-cleaving ribozymes. However, a model o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-08-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/15/8/5389/ |