Deep neural network based tissue deconvolution of circulating tumor cell RNA

Abstract Prior research has shown that the deconvolution of cell-free RNA can uncover the tissue origin. The conventional deconvolution approaches rely on constructing a reference tissue-specific gene panel, which cannot capture the inherent variation present in actual data. To address this, we have...

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Bibliographic Details
Main Authors: Fengyao Yan, Limin Jiang, Fei Ye, Jie Ping, Tetiana Y. Bowley, Scott A. Ness, Chung-I Li, Dario Marchetti, Jijun Tang, Yan Guo
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Translational Medicine
Online Access:https://doi.org/10.1186/s12967-023-04663-w