MPTAC links alkylation damage signaling to sterol biosynthesis

MPTAC links alkylation damage signaling to sterol biosynthesis

Overproduction of reactive oxygen species (ROS) drives inflammation and mutagenesis. However, the role of the DNA damage response in immune responses remains largely unknown. Here we found that stabilization of the mismatch repair (MMR) protein MSH6 in response to alkylation damage requires interact...

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Bibliographic Details
Main Authors: Tamaki Suganuma, Jerry L. Workman
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Redox Biology
Subjects:
MPTAC
ATAC
MSH6
Alkylation damage
Mevalonate pathway
Sterol biosynthesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722000428

Internet

http://www.sciencedirect.com/science/article/pii/S2213231722000428

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