MITF Is Regulated by Redox Signals Controlled by the Selenoprotein Thioredoxin Reductase 1

MITF Is Regulated by Redox Signals Controlled by the Selenoprotein Thioredoxin Reductase 1

TR1 and other selenoproteins have paradoxical effects in melanocytes and melanomas. Increasing selenoprotein activity with supplemental selenium in a mouse model of UV-induced melanoma prevents oxidative damage to melanocytes and delays melanoma tumor formation. However, TR1 itself is positively ass...

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Bibliographic Details
Main Authors: Chelsey D. Kline, Madeleine Anderson, John W. Bassett, Gail Kent, Rachel Berryman, Matthew Honeggar, Shosuke Ito, Kazumasa Wakamatsu, Arup K. Indra, Philip J. Moos, Sancy A. Leachman, Pamela B. Cassidy
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
thioredoxin reductase 1
MITF
redox signaling
peroxiredoxin
glutathione
Online Access:https://www.mdpi.com/2072-6694/14/20/5011

Internet

https://www.mdpi.com/2072-6694/14/20/5011

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