IL-15 armoring enhances the antitumor efficacy of claudin 18.2-targeting CAR-T cells in syngeneic mouse tumor models

IL-15 armoring enhances the antitumor efficacy of claudin 18.2-targeting CAR-T cells in syngeneic mouse tumor models

Claudin 18.2 (CLDN18.2)-targeting chimeric antigen receptor (CAR)-modified T cells are one of the few cell therapies currently producing an impressive therapeutic effect in treating solid tumors; however, their long-term therapeutic efficacy is not satisfactory with a short duration of response. Tra...

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Bibliographic Details
Main Authors: Hongtai Shi, Andi Li, Zhenyu Dai, Jiao Xue, Qi Zhao, Jiyuan Tian, Dandan Song, Hao Wang, Jianan Chen, Xiaokang Zhang, Kaisong Zhou, Huafeng Wei, Songbing Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
claudin 18.2
CAR T cells
IL-15
solid tumor
cellular therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1165404/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1165404/full

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