Gold Nanoparticles Inhibit Steroid-Insensitive Asthma in Mice Preserving Histone Deacetylase 2 and NRF2 Pathways

Gold Nanoparticles Inhibit Steroid-Insensitive Asthma in Mice Preserving Histone Deacetylase 2 and NRF2 Pathways

Background: Gold nanoparticles (AuNPs) can inhibit pivotal pathological changes in experimental asthma, but their effect on steroid-insensitive asthma is unclear. The current study assessed the effectiveness of nebulized AuNPs in a murine model of glucocorticoid (GC)-resistant asthma. Methods: A/J m...

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Bibliographic Details
Main Authors: Magda F. Serra, Amanda C. Cotias, Andreza S. Pimentel, Ana Carolina S. de Arantes, Ana Lucia A. Pires, Manuella Lanzetti, Jandir M. Hickmann, Emiliano Barreto, Vinicius F. Carvalho, Patrícia M. R. e Silva, Renato S. B. Cordeiro, Marco Aurélio Martins
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Antioxidants
Subjects:
gold nanoparticle
steroid-insensitive asthma
lung inflammation
NRF2
HDAC2
oxidative imbalance
Online Access:https://www.mdpi.com/2076-3921/11/9/1659

Internet

https://www.mdpi.com/2076-3921/11/9/1659

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