3-Chloro-3-methyl-2,6-diarylpiperidin-4-ones as Anti-Cancer Agents: Synthesis, Biological Evaluation, Molecular Docking, and In Silico ADMET Prediction

3-Chloro-3-methyl-2,6-diarylpiperidin-4-ones as Anti-Cancer Agents: Synthesis, Biological Evaluation, Molecular Docking, and In Silico ADMET Prediction

Piperidine pharmacophore-containing compounds have demonstrated therapeutic efficacy against a range of diseases and are now being investigated in cancer. A series of 3-chloro-3-methyl-2,6-diarylpiperidin-4-ones, compounds (<b>I</b>–<b>V</b>) were designed and synthesized for...

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Bibliographic Details
Main Authors: Arulraj Ramalingam, Nurulhuda Mustafa, Wee Joo Chng, Mouna Medimagh, Sivakumar Sambandam, Noureddine Issaoui
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomolecules
Subjects:
piperidin-4-ones
myeloma
leukemia
lymphoma
molecular docking calculation
computational ADMET
Online Access:https://www.mdpi.com/2218-273X/12/8/1093

Internet

https://www.mdpi.com/2218-273X/12/8/1093

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