Novel anti-metastatic action of cidofovir mediated by inhibition of E6/E7, CXCR4 and Rho/ROCK signaling in HPV tumor cells.

Novel anti-metastatic action of cidofovir mediated by inhibition of E6/E7, CXCR4 and Rho/ROCK signaling in HPV tumor cells.

Cervical cancer is frequently associated with HPV infection. The expression of E6 and E7 HPV oncoproteins is a key factor in its carcinogenicity and might also influence its virulence, including metastatic conversion. The cellular mechanisms involved in metastatic spread remain elusive, but pro-adhe...

Full description

Bibliographic Details
Main Authors: Abdessamad Amine, Sofia Rivera, Paule Opolon, Mehdi Dekkal, Denis S F Biard, Hakim Bouamar, Fawzia Louache, Michael J McKay, Jean Bourhis, Eric Deutsch, Marie-Catherine Vozenin-Brotons
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2657827?pdf=render

Internet

http://europepmc.org/articles/PMC2657827?pdf=render

Similar Items