Fibroblasts Influence Metastatic Melanoma Cell Sensitivity to Combined BRAF and MEK Inhibition

Fibroblasts Influence Metastatic Melanoma Cell Sensitivity to Combined BRAF and MEK Inhibition

The sensitivity of melanoma cells to targeted therapy compounds depends on the tumor microenvironment. Three-dimensional (3D) in vitro coculture systems better reflect the native structural architecture of tissues and are ideal for investigating cellular interactions modulating cell sensitivity to d...

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Bibliographic Details
Main Authors: Delphine Morales, Pascale Vigneron, Ines Ferreira, Warda Hamitou, Mikael Magnano, Laxsika Mahenthiran, Catherine Lok, Muriel Vayssade
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
targeted therapy
tissue engineering
3D human melanoma model
BRAFi + MEKi efficiency
cancer-associated fibroblasts
Online Access:https://www.mdpi.com/2072-6694/13/19/4761

Internet

https://www.mdpi.com/2072-6694/13/19/4761

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