Fibroblasts Influence Metastatic Melanoma Cell Sensitivity to Combined BRAF and MEK Inhibition
The sensitivity of melanoma cells to targeted therapy compounds depends on the tumor microenvironment. Three-dimensional (3D) in vitro coculture systems better reflect the native structural architecture of tissues and are ideal for investigating cellular interactions modulating cell sensitivity to d...
Main Authors: | Delphine Morales, Pascale Vigneron, Ines Ferreira, Warda Hamitou, Mikael Magnano, Laxsika Mahenthiran, Catherine Lok, Muriel Vayssade |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-09-01
|
Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/13/19/4761 |
Similar Items
-
Oxidative Stress-Related Mechanisms in Melanoma and in the Acquired Resistance to Targeted Therapies
by: Stefania Pizzimenti, et al.
Published: (2021-12-01) -
Nrf2 as a Therapeutic Target in the Resistance to Targeted Therapies in Melanoma
by: Marie Angèle Cucci, et al.
Published: (2023-06-01) -
Biomarkers in metastatic melanoma of the skin: can we more accurately choose the tactics of treating our patients?
by: A. R. Zaretsky, et al.
Published: (2021-08-01) -
Enhancing Therapeutic Efficacy of Oncolytic Herpes Simplex Virus with MEK Inhibitor Trametinib in Some BRAF or KRAS-Mutated Colorectal or Lung Carcinoma Models
by: XuSha Zhou, et al.
Published: (2021-09-01) -
MEK inhibitors for the treatment of extracranial arteriovenous malformations
by: Zi’an Xu, et al.
Published: (2023-09-01)