LALAPG variant of the Human Contraception Antibody (HCA) reduces Fc-mediated effector functions while maintaining sperm agglutination activity

LALAPG variant of the Human Contraception Antibody (HCA) reduces Fc-mediated effector functions while maintaining sperm agglutination activity

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High rates of unintended pregnancies worldwide indicate a need for more accessible and acceptable methods of contraception. We have developed a monoclonal antibody, the Human Contraception Antibody (HCA), for use by women in vaginal films and rings for contraception. The divalent F(ab’)2 region of H...

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Bibliographic Details
Main Authors: Emilie Mausser, Ellena Nador, Joseph A. Politch, Michael R. Pauly, Jai G. Marathe, Thomas R. Moench, Larry Zeitlin, Kevin J. Whaley, Deborah J. Anderson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062632/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062632/?tool=EBI

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