Mannich-type modifications of (−)-cannabidiol and (−)-cannabigerol leading to new, bioactive derivatives

Mannich-type modifications of (−)-cannabidiol and (−)-cannabigerol leading to new, bioactive derivatives

Abstract (−)-Cannabidiol (CBD) and (−)-cannabigerol (CBG) are two major non-psychotropic phytocannabinoids that have many beneficial biological properties. However, due to their low water solubility and prominent first-pass metabolism, their oral bioavailability is moderate, which is unfavorable for...

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Bibliographic Details
Main Authors: Eszter Boglárka Lőrincz, Gergely Tóth, Júlia Spolárics, Mihály Herczeg, Jan Hodek, István Zupkó, Renáta Minorics, Dorottya Ádám, Attila Oláh, Christos C. Zouboulis, Jan Weber, Lajos Nagy, Eszter Ostorházi, Ildikó Bácskay, Anikó Borbás, Pál Herczegh, Ilona Bereczki
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-45565-7

Internet

https://doi.org/10.1038/s41598-023-45565-7

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