21-Hydroxylase-Specific CD8+ T Cells in Autoimmune Addison’s Disease Are Restricted by HLA-A2 and HLA-C7 Molecules

21-Hydroxylase-Specific CD8+ T Cells in Autoimmune Addison’s Disease Are Restricted by HLA-A2 and HLA-C7 Molecules

ObjectivesCD8+ T cells targeting 21-hydroxylase (21OH) are presumed to play a central role in the destruction of adrenocortical cells in autoimmune Addison’s disease (AAD). Earlier reports have suggested two immunodominant CD8+ T cell epitopes within 21OH: LLNATIAEV (21OH342-350), restricted by HLA-...

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Bibliographic Details
Main Authors: Alexander Hellesen, Sigrid Aslaksen, Lars Breivik, Ellen Christine Røyrvik, Øyvind Bruserud, Kine Edvardsen, Karl Albert Brokstad, Anette Susanne Bøe Wolff, Eystein Sverre Husebye, Eirik Bratland
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
CD8+ T cells
21-hydroxylase
autoimmune
Addison’s disease
epitopes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.742848/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.742848/full

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