Single-Cell Transcriptomics Identifies Heterogeneity of Mouse Mammary Gland Fibroblasts With Distinct Functions, Estrogen Responses, Differentiation Processes, and Crosstalks With Epithelium

Single-Cell Transcriptomics Identifies Heterogeneity of Mouse Mammary Gland Fibroblasts With Distinct Functions, Estrogen Responses, Differentiation Processes, and Crosstalks With Epithelium

Fibroblasts have been shown to be one of the essential players for mammary gland organization. Here, we identify two major types of mouse mammary gland fibroblasts through single-cell RNA sequencing analysis: Dpp4+ fibroblasts and Dpp4- fibroblasts. Each population exhibits unique functional charact...

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Bibliographic Details
Main Authors: Ryohei Yoshitake, Gregory Chang, Kohei Saeki, Desiree Ha, Xiwei Wu, Jinhui Wang, Shiuan Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cell-cell interaction
estrogen
fibroblasts
mammary gland
single-cell RNA sequencing
trajectory analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.850568/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.850568/full

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