Ring-stage growth arrest: Metabolic basis of artemisinin tolerance in Plasmodium falciparum

Ring-stage growth arrest: Metabolic basis of artemisinin tolerance in Plasmodium falciparum

Summary: The emergence and spread of artemisinin-tolerant malaria parasites threatens malaria control programmes worldwide. Mutations in the propeller domain of the Kelch13 protein confer Plasmodium falciparum artemisinin resistance (ART-R). ART-R is linked to the reduced susceptibility of temporary...

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Bibliographic Details
Main Authors: Xinyu Yu, Changhong Wang, Yuemeng Zhao, Jianxia Tang, Meng Zhu, Lucien Platon, Richard Culleton, Guoding Zhu, Didier Ménard, Qingfeng Zhang, Jun Cao
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:iScience
Subjects:
Multidrug resistant organisms
Parasitology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222019988

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http://www.sciencedirect.com/science/article/pii/S2589004222019988

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