Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice

Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice

A major asset of many monoclonal antibody (mAb)-based biologics is their persistence in circulation. The MHC class I family Fc receptor, FCGRT, is primarily responsible for this extended pharmacokinetic behavior. Engagement of FCGRT with the crystallizable fragment (Fc) domain protects IgG from cata...

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Bibliographic Details
Main Authors: Benjamin E. Low, Gregory J. Christianson, Emily Lowell, Wenning Qin, Michael V. Wiles
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:mAbs
Subjects:
Gene editing
mAb
monoclonal antibody
IgG
neonatal Fc receptor (FcRn)
humanized antibodies
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2020.1829334

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2020.1829334

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