A Thiazole Orange Derivative Targeting the Bacterial Protein FtsZ Shows Potent Antibacterial Activity

A Thiazole Orange Derivative Targeting the Bacterial Protein FtsZ Shows Potent Antibacterial Activity

The prevalence of multidrug resistance among clinically significant bacteria calls for the urgent development of new antibiotics with novel mechanisms of action. In this study, a new small molecule exhibiting excellent inhibition of bacterial cell division with potent antibacterial activity was disc...

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Bibliographic Details
Main Authors: Ning Sun, Yu-Jing Lu, Fung-Yi Chan, Ruo-Lan Du, Yuan-yuan Zheng, Kun Zhang, Lok-Yan So, Ruben Abagyan, Chao Zhuo, Yun-Chung Leung, Kwok-Yin Wong
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Microbiology
Subjects:
bacterial resistance
antibacterial activity
cell division
FtsZ inhibitor
FtsZ polymerization
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.00855/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.00855/full

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