Epigenetic and transcriptional dysregulation in CD4+ T cells in patients with atopic dermatitis.

Epigenetic and transcriptional dysregulation in CD4+ T cells in patients with atopic dermatitis.

Atopic dermatitis (AD) is one of the most common skin disorders among children. Disease etiology involves genetic and environmental factors, with 29 independent AD risk loci enriched for risk allele-dependent gene expression in the skin and CD4+ T cell compartments. We investigated the potential epi...

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Bibliographic Details
Main Authors: Amy A Eapen, Sreeja Parameswaran, Carmy Forney, Lee E Edsall, Daniel Miller, Omer Donmez, Katelyn Dunn, Xiaoming Lu, Marissa Granitto, Hope Rowden, Adam Z Magier, Mario Pujato, Xiaoting Chen, Kenneth Kaufman, David I Bernstein, Ashley L Devonshire, Marc E Rothenberg, Matthew T Weirauch, Leah C Kottyan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-05-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009973

Internet

https://doi.org/10.1371/journal.pgen.1009973

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