KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis

KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis

Abstract Background Frequent truncation mutations of the histone lysine N-methyltransferase KMT2C have been detected by whole exome sequencing studies in various cancers, including malignancies of the prostate. However, the biological consequences of these alterations in prostate cancer have not yet...

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Bibliographic Details
Main Authors: Tanja Limberger, Michaela Schlederer, Karolina Trachtová, Ines Garces de los Fayos Alonso, Jiaye Yang, Sandra Högler, Christina Sternberg, Vojtech Bystry, Jan Oppelt, Boris Tichý, Margit Schmeidl, Petra Kodajova, Anton Jäger, Heidi A. Neubauer, Monika Oberhuber, Belinda S. Schmalzbauer, Sarka Pospisilova, Helmut Dolznig, Wolfgang Wadsak, Zoran Culig, Suzanne D. Turner, Gerda Egger, Sabine Lagger, Lukas Kenner
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Molecular Cancer
Subjects:
Prostate cancer
Senescence
Metastasis
KMT2C
MYC
p16INK4A
Online Access:https://doi.org/10.1186/s12943-022-01542-8

Internet

https://doi.org/10.1186/s12943-022-01542-8

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