STIL binding to Polo-box 3 of PLK4 regulates centriole duplication

STIL binding to Polo-box 3 of PLK4 regulates centriole duplication

Polo-like kinases (PLK) are eukaryotic regulators of cell cycle progression, mitosis and cytokinesis; PLK4 is a master regulator of centriole duplication. Here, we demonstrate that the SCL/TAL1 interrupting locus (STIL) protein interacts via its coiled-coil region (STIL-CC) with PLK4 in vivo. STIL-C...

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Bibliographic Details
Main Authors: Christian Arquint, Anna-Maria Gabryjonczyk, Stefan Imseng, Raphael Böhm, Evelyn Sauer, Sebastian Hiller, Erich A Nigg, Timm Maier
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-07-01
Series:eLife
Subjects:
centriole duplication
cell cycle
NMR
X-ray crystallography
Online Access:https://elifesciences.org/articles/07888

Internet

https://elifesciences.org/articles/07888

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