Mapping the epigenomic landscape of human monocytes following innate immune activation reveals context-specific mechanisms driving endotoxin tolerance

Mapping the epigenomic landscape of human monocytes following innate immune activation reveals context-specific mechanisms driving endotoxin tolerance

Abstract Background Monocytes are key mediators of innate immunity to infection, undergoing profound and dynamic changes in epigenetic state and immune function which are broadly protective but may be dysregulated in disease. Here, we aimed to advance understanding of epigenetic regulation following...

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Bibliographic Details
Main Authors: Harindra E. Amarasinghe, Ping Zhang, Justin P. Whalley, Alice Allcock, Gabriele Migliorini, Andrew C. Brown, Giuseppe Scozzafava, Julian C. Knight
Format: Article
Language:English
Published: BMC 2023-10-01
Series:BMC Genomics
Subjects:
Endotoxin tolerance
Human monocytes
Context-specificity
Chromatin accessibility
Enhancer RNA
Expression quantitative trait loci
Online Access:https://doi.org/10.1186/s12864-023-09663-0

Internet

https://doi.org/10.1186/s12864-023-09663-0

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