Hydroxysafflor yellow A protects against thioacetamide-induced liver fibrosis in rats via suppressing proinflammatory/fibrogenic mediators and promoting hepatic stellate cell senescence and apoptosis

Hydroxysafflor yellow A protects against thioacetamide-induced liver fibrosis in rats via suppressing proinflammatory/fibrogenic mediators and promoting hepatic stellate cell senescence and apoptosis

Objective: To evaluate the effect of hydroxysafflor yellow A (HSYA) on thioacetamide-induced liver fibrosis. Methods: Thioacetamide was administered to rats intraperitoneally in doses of 200 mg/kg twice a week for 12 weeks. Thioacetamide-intoxicated rats were given silymarin (50 mg/kg) or HSYA (5 mg...

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Bibliographic Details
Main Authors: Sayed H. Seif el-Din, Olfat A. Hammam, Shahira M. Ezzat, Samira Saleh, Marwa M. Safar, Walaa H. El-Maadawy, Naglaa M. El-Lakkany
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Asian Pacific Journal of Tropical Biomedicine
Subjects:
hydroxysafflor yellow a; thioacetamide; hepatic stellate cells; inflammatory markers; liver fibrosis; p21; α-sma apoptosis
Online Access:http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=8;spage=348;epage=358;aulast=el-Din

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http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=8;spage=348;epage=358;aulast=el-Din

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