Separating the signal from the noise in metagenomic cell-free DNA sequencing

Separating the signal from the noise in metagenomic cell-free DNA sequencing

Abstract Background Cell-free DNA (cfDNA) in blood, urine, and other biofluids provides a unique window into human health. A proportion of cfDNA is derived from bacteria and viruses, creating opportunities for the diagnosis of infection via metagenomic sequencing. The total biomass of microbial-deri...

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Main Authors: Philip Burnham, Nardhy Gomez-Lopez, Michael Heyang, Alexandre Pellan Cheng, Joan Sesing Lenz, Darshana M. Dadhania, John Richard Lee, Manikkam Suthanthiran, Roberto Romero, Iwijn De Vlaminck
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Microbiome
Subjects:
Cell-free DNA
Metagenomics
Biomarkers
Infectious disease
Prenatal health
Online Access:https://doi.org/10.1186/s40168-020-0793-4

Internet

https://doi.org/10.1186/s40168-020-0793-4

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