Lipophilic analogues of D-cysteine prevent and reverse physical dependence to fentanyl in male rats

Lipophilic analogues of D-cysteine prevent and reverse physical dependence to fentanyl in male rats

We examined whether co-injections of the cell-permeant D-cysteine analogues, D-cysteine ethyl ester (D-CYSee) and D-cysteine ethyl amide (D-CYSea), prevent acquisition of physical dependence induced by twice-daily injections of fentanyl, and reverse acquired dependence to these injections in freely-...

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Bibliographic Details
Main Authors: James N. Bates, Paulina M. Getsy, Gregory A. Coffee, Santhosh M. Baby, Peter M. MacFarlane, Yee-Hsee Hsieh, Zackery T. Knauss, Jason A. Bubier, Devin Mueller, Stephen J. Lewis
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Pharmacology
Subjects:
fentanyl
physical dependence
D-cysteine ethyl ester
D-cysteine ethyl amide
naloxone
withdrawal phenomena
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1336440/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1336440/full

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