Bacterial vesicles block viral replication in macrophages via TLR4-TRIF-axis

Bacterial vesicles block viral replication in macrophages via TLR4-TRIF-axis

Abstract Gram-negative bacteria naturally secrete nano-sized outer membrane vesicles (OMVs), which are important mediators of communication and pathogenesis. OMV uptake by host cells activates TLR signalling via transported PAMPs. As important resident immune cells, alveolar macrophages are located...

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Bibliographic Details
Main Authors: Jeff Bierwagen, Marie Wiegand, Katrin Laakmann, Olga Danov, Hannah Limburg, Stefanie Muriel Herbel, Thomas Heimerl, Jens Dorna, Danny Jonigk, Christian Preußer, Wilhelm Bertrams, Armin Braun, Katherina Sewald, Leon N. Schulte, Stefan Bauer, Elke Pogge von Strandmann, Eva Böttcher-Friebertshäuser, Bernd Schmeck, Anna Lena Jung
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Cell Communication and Signaling
Subjects:
Extracellular vesicles
Outer membrane vesicles
Bacterial and viral co-infection
Pneumonia
Macrophage
Alveolar epithelial cell
Online Access:https://doi.org/10.1186/s12964-023-01086-4

Internet

https://doi.org/10.1186/s12964-023-01086-4

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