Contribution of intestinal smooth muscle to Crohn's disease fibrogenesis

Contribution of intestinal smooth muscle to Crohn's disease fibrogenesis

<p>Mesenchymal cells transdifferentiation and extracellular matrix deposition are involved in the fibrotic process of Crohn’s disease (CD). Mesenchymal smooth muscle cells (SMCs) de-differentiation, driven by Platelet-derived growth factor (PDGF) that counteracts Transforming growth factor (TG...

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Bibliographic Details
Main Authors: C. Severi, R. Sferra, A. Scirocco, A. Vetuschi, N. Pallotta, A. Pronio, R. Caronna, G. Di Rocco, E. Gaudio, E. Corazziari, P. Onori
Format: Article
Language:English
Published: PAGEPress Publications 2014-10-01
Series:European Journal of Histochemistry
Subjects:
Fibrosis
Crohn’s disease
ileal smooth muscle cells
stricture formation
PDGF
TGF-β.
Online Access:http://www.ejh.it/index.php/ejh/article/view/2457

Internet

http://www.ejh.it/index.php/ejh/article/view/2457

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