Pro-apoptotic and anti-angiogenic actions of 2-methoxyestradiol and docosahexaenoic acid, the biologically derived active compounds from flaxseed diet, in preventing ovarian cancer

Pro-apoptotic and anti-angiogenic actions of 2-methoxyestradiol and docosahexaenoic acid, the biologically derived active compounds from flaxseed diet, in preventing ovarian cancer

Abstract Background We have previously shown that a whole flaxseed supplemented diet decreased the onset and severity of ovarian cancer in the laying hen, the only known animal model of spontaneous ovarian cancer. Flaxseed is rich in omega-3 fatty acids (OM3FA), mostly α-Linoleic acid (ALA), which g...

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Bibliographic Details
Main Authors: Purab Pal, Karen Hales, Jim Petrik, Dale Buchanan Hales
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Ovarian Research
Subjects:
Ovarian cancer
Flaxseed
2-methoxyestradiol
Docosahexaenoic acid
p38-MAPK
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s13048-019-0523-3

Internet

http://link.springer.com/article/10.1186/s13048-019-0523-3

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