Application of simultaneous selective pressures slows adaptation

Application of simultaneous selective pressures slows adaptation

Abstract Beneficial mutations that arise in an evolving asexual population may compete or interact in ways that alter the overall rate of adaptation through mechanisms such as clonal or functional interference. The application of multiple selective pressures simultaneously may allow for a greater nu...

Full description

Bibliographic Details
Main Authors: Lauren M. F. Merlo, Kathleen Sprouffske, Taylor C. Howard, Kristin L. Gardiner, Aleah F. Caulin, Steven M. Blum, Perry Evans, Antonio Bedalov, Paul D. Sniegowski, Carlo C. Maley
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Evolutionary Applications
Subjects:
adaptation
cancer therapy
clonal interference
functional interference
slowing evolution
Online Access:https://doi.org/10.1111/eva.13062

Internet

https://doi.org/10.1111/eva.13062

Similar Items