Shikonin Induces ROS-Dependent Apoptosis Via Mitochondria Depolarization and ER Stress in Adult T Cell Leukemia/Lymphoma

Shikonin Induces ROS-Dependent Apoptosis Via Mitochondria Depolarization and ER Stress in Adult T Cell Leukemia/Lymphoma

Adult T cell leukemia/lymphoma (ATLL) is an aggressive T-cell malignancy that develops in some elderly human T-cell leukemia virus (HTVL-1) carriers. ATLL has a poor prognosis despite conventional and targeted therapies, and a new safe and efficient therapy is required. Here, we examined the anti-AT...

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Bibliographic Details
Main Authors: Piyanard Boonnate, Ryusho Kariya, Seiji Okada
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Antioxidants
Subjects:
Shikonin (SHK)
adult T cell leukemia/lymphoma (ATLL)
Reactive Oxygen Species (ROS)
mitochondria depolarization
endoplasmic reticulum (ER) stress
apoptosis
Online Access:https://www.mdpi.com/2076-3921/12/4/864

Internet

https://www.mdpi.com/2076-3921/12/4/864

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