Rhein Protects against Obesity and Related Metabolic Disorders through Liver X Receptor-Mediated Uncoupling Protein 1 Upregulation in Brown Adipose Tissue

<p>Liver X receptors (LXRs) play important roles in regulating cholesterol homeostasis, and lipid and energy metabolism. Therefore, LXR ligands could be used for the management of metabolic disorders. We evaluated rhein, a natural compound from <i>Rheum palmatum </i>L., as an antag...

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Bibliographic Details
Main Author: Xiaoyan Sheng, Xuehua Zhu, Yuebo Zhang, Guoliang Cui, Linling Peng, Xiong Lu, Ying Qin Zang
Format: Article
Language:English
Published: Ivyspring International Publisher 2012-01-01
Series:International Journal of Biological Sciences
Online Access:http://www.biolsci.org/v08p1375.htm