Autoimmune Memory T Helper 17 Cell Function and Expansion Are Dependent on Interleukin-23

Autoimmune Memory T Helper 17 Cell Function and Expansion Are Dependent on Interleukin-23

Interleukin-23 (IL-23) is essential for the differentiation of pathogenic effector T helper 17 (Th17) cells, but its role in memory Th17 cell responses is unclear. Using the experimental autoimmune encephalomyelitis (EAE) model, we report that memory Th17 cells rapidly expanded in response to rechal...

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Bibliographic Details
Main Authors: Christopher J. Haines, Yi Chen, Wendy M. Blumenschein, Renu Jain, Charlie Chang, Barbara Joyce-Shaikh, Katherine Porth, Katia Boniface, Jeanine Mattson, Beth Basham, Stephen M. Anderton, Terrill K. McClanahan, Svetlana Sadekova, Daniel J. Cua, Mandy J. McGeachy
Format: Article
Language:English
Published: Elsevier 2013-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713001599

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http://www.sciencedirect.com/science/article/pii/S2211124713001599

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