Design, Synthesis and Biological Evaluation of New Piperazin-4-yl-(acetyl-thiazolidine-2,4-dione) Norfloxacin Analogues as Antimicrobial Agents

Design, Synthesis and Biological Evaluation of New Piperazin-4-yl-(acetyl-thiazolidine-2,4-dione) Norfloxacin Analogues as Antimicrobial Agents

In an effort to improve the antimicrobial activity of norfloxacin, a series of hybrid norfloxacin−thiazolidinedione molecules were synthesized and screened for their direct antimicrobial activity and their anti-biofilm properties. The new hybrids were intended to have a new binding mode to...

Full description

Bibliographic Details
Main Authors: Gabriel Marc, Cătălin Araniciu, Smaranda Dafina Oniga, Laurian Vlase, Adrian Pîrnău, George Cosmin Nadăș, Cristiana Ștefania Novac, Ioana Adriana Matei, Mariana Carmen Chifiriuc, Luminița Măruțescu, Ovidiu Oniga
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Molecules
Subjects:
norfloxacin
thiazolidinedione
anti-biofilm
anti-bacterial
dna gyrase
antibiotic resistance
fluoroquinolones
Online Access:https://www.mdpi.com/1420-3049/24/21/3959

Internet

https://www.mdpi.com/1420-3049/24/21/3959

Similar Items