Model selection and robust inference of mutational signatures using Negative Binomial non-negative matrix factorization

Model selection and robust inference of mutational signatures using Negative Binomial non-negative matrix factorization

Abstract Background The spectrum of mutations in a collection of cancer genomes can be described by a mixture of a few mutational signatures. The mutational signatures can be found using non-negative matrix factorization (NMF). To extract the mutational signatures we have to assume a distribution fo...

Full description

Bibliographic Details
Main Authors: Marta Pelizzola, Ragnhild Laursen, Asger Hobolth
Format: Article
Language:English
Published: BMC 2023-05-01
Series:BMC Bioinformatics
Subjects:
Cancer genomics
Cross-validation
Model checking
Model selection
Mutational signatures
Negative Binomial
Online Access:https://doi.org/10.1186/s12859-023-05304-1

Internet

https://doi.org/10.1186/s12859-023-05304-1

Similar Items