QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology

QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology

The mitochondrial contact site and cristae junction (CJ) organizing system (MICOS) dynamically regulate mitochondrial membrane architecture. Through systematic proteomic analysis of human MICOS, we identified QIL1 (C19orf70) as a novel conserved MICOS subunit. QIL1 depletion disrupted CJ structure i...

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Bibliographic Details
Main Authors: Virginia Guarani, Elizabeth M McNeill, Joao A Paulo, Edward L Huttlin, Florian Fröhlich, Steven P Gygi, David Van Vactor, J Wade Harper
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-05-01
Series:eLife
Subjects:
mitochondria
proteomics
protein complex
Online Access:https://elifesciences.org/articles/06265

Internet

https://elifesciences.org/articles/06265

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