QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology
The mitochondrial contact site and cristae junction (CJ) organizing system (MICOS) dynamically regulate mitochondrial membrane architecture. Through systematic proteomic analysis of human MICOS, we identified QIL1 (C19orf70) as a novel conserved MICOS subunit. QIL1 depletion disrupted CJ structure i...
Main Authors: | Virginia Guarani, Elizabeth M McNeill, Joao A Paulo, Edward L Huttlin, Florian Fröhlich, Steven P Gygi, David Van Vactor, J Wade Harper |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2015-05-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/06265 |
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